| Takara 国产RetroNectin®新品促销活动进行中 | ||||||||||||
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| ■ 最新优秀论文 | ||||||||||||
| Duo Zhang,Protocol to generate traceable CAR T cells for syngeneic mouse cancer models. | ||||||||||||
| 说明： 为回馈广大客户，我公司决定推出针对细胞治疗的新产品Takara国产RetroNectin®，新品促销价300元/支，4支起订，如果单独订购1支，按优惠价550元/支，2024年03月20日起开始执行，如需订购请联系所有Takara代理商。 单次订购满15支的客户有精美礼品赠送。 促销起始日期：2024年04月28日 促销截止日期：另行通知 温馨提示：关于此产品的订购和技术疑问，请致电010-80720983 |
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| Retronectin 制备CAR-T部分文献 | ||||||||||||
| 1: Okuma A. Generation of CAR-T Cells by Lentiviral Transduction. 2: Nasiri F . Effects of polybrene and retronectin as transduction enhancers on the development and phenotypic characteristics of VHH-based CD19-redirected CAR T cells: a comparative investigation. 3: Rajabzadeh A.highly enhance the gene transduction efficiency of Mucin-1-specific chimeric antigen receptor (CAR) in human primary T cells. 4：Dan Lu. KRAS G12V neoantigen specific T cell receptor for adoptive T cell therapy against tumors. 5：Chen Wang, Circadian tumor infiltration and function of CD8 + T cells dictate immunotherapy efficacy. 6：Xin Zhang, The cell cycle regulator p16 promotes tumor infiltrated CD8 + T cell exhaustion and apoptosis. 7：Yue Hu，Selective refueling of CAR T cells using ADA1 and CD26 boosts antitumor immunity. 8：Duo Zhang,Protocol to generate traceable CAR T cells for syngeneic mouse cancer models. |
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| Retronectin 刺激淋巴细胞活化扩增部分文献 | ||||||||||||
| 1: Zhao L, Clinical value of neutrophil-to-lymphocyte ratio as a predictor of prognosis of RetroNectin-activated cytokine-induced killer cell therapy in advanced non-small-cell lung cancer. 2: Gong W, Evaluation of Production Protocols for the Generation of NY-ESO-1-Specific T Cells. Cells. 3: Zhao L, Pseudoprogression: an indicator for cure in combined immunotherapy? |
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| ♥ 产品特点 | ||||||||||||
| ● 可以将逆转录病毒中的目的基因高效转入造血干细胞、T淋巴细胞等哺乳动物来源的细胞。 ● 避免感染过程中因使用polybrene造成的细胞毒作用。 ● 同样适用于感染常规的细胞系。 ● RetroNectin是重组人纤维连接蛋白片段，包括细胞结合域，肝磷脂结合域和CS1位点三个功能区域。它由574个氨基酸组成，分子量63 kDa。RetroNectin能够大大的提高逆转录病毒感染哺乳动物细胞的感染效率，其作用原理是：细胞表面VLA-4及VLA-5可分别于RetroNectin上的CS-1位点及细胞结合域结合，逆转录病毒载体可以与肝磷脂结合域结合。在经RetroNectin包被的培养容器表面，细胞与病毒载体以高浓度共存，从而提高基因转染效率30%-70%。 ● 另外RetroNectin还可以刺激淋巴细胞增殖，尤其是胸腹水以及肿瘤组织分离的TIL细胞，利用RetroNectin技术均可使其获得上千倍的增殖，已有部分客户将RetroNectin技术扩增TIL的方法进行专利申请。 |
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